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Selected publications:


  • Zhang Y*, Tang Y*, Sun Z, Jia J, Fang Y, Wan X, Fang D#. Tn5 tagments and transposes oligos to single-stranded DNA for strand-specific RNA sequencing. Genome Research, 2023, 33412-426.

  • Zhang Y*, Fang Y*, Tang Y*, Han S, Jia J, Wan X, Chen J, Yuan Y,  Zhao B and Fang D#. SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters. Nature Communications, 2022, 133190.

  • Sun Z*, Tang Y*, Zhang Y*, Fang Y*, Jia J, Zeng W, Fang D#. Joint single-cell multiomic analysis in Wnt3a induced asymmetric stem cell division. Nature Communications, 2021,12, 5941.

  • Fang Y*, Tang Y*, Zhang Y*, Pan Y*, Jia J, Sun Z, Zeng W, Chen J, Yuan Y, Fang D#. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression. Nucleic Acids Research2021, 11:6281–6295.

  • Zhang Y, Fang D#. The incorporation loci of H3.3K36M determine its preferential prevalence in chondroblastomas. Cell Death and Disease, 2021, 12, 311.

  • Liu Y, Zhang Y, Xue H, Cao M, Bai G, Mu Z, Yao Y, Sun S, Fang D#, Huang J#. Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations. Cell Discovery,2021, 7, 32.

  • Sun Z*, Zhang Y*, Jia J, Fang Y, Tang Y, Wu H, Fang D#. H3K36me3, message from chromatin to DNA damage repair. Cell Bioscience, 2020, 10, 9.

  • Fang D*, Gan H*, Cheng L, Lee J, Zhou H, Sarkaria J, Daniels D, Zhang Z#. H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. eLife, 2018, 7:e36696.

  • Fang D, Gan H, Wang H, Zhou H, Zhang Z#. Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells. Cell Cycle, 2017, 16(19): 1781-1789.

  • Fang D*, Gan H*, Lee J*, Han J*, Wang Z*, Riester S, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley E, Ho T, Rubin B, Bridge J, Thibodeau S, Ordog T, Chen Y, Wijnen A, Oliveira A, Xu R, Westerdorf J, Zhang Z#. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 2016, 352(6291): 1344-1348.

  • Hashizume R#, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nature Medicine, 2014, doi:10.1038/nm.3716

  • Pan C, Fang D, Xu G, Liang J, Zhang G, Wang H, Xie L#, Zhang R#. A novel acidic matrix protein, PfN44, stabilizes magnesium calcite to inhibit the crystallization of aragonite. Journal of Biological Chemistry, 2014: 289(5), 2776-87.

  • Chan KM*, Han J*, Fang D*, Gan H, Zhang Z#. A lesson learned from the H3.3K27M mutation found in pediatric glioma: A new approach to the study of the function of histone modifications in vivo. Cell Cycle, 2013:12:2546 – 2552.

  • Chan KM*, Fang D*, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z#. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes and Development, 2013, 27(9):985-990.

  • Fang D, Pan C, Lin HJ, Lin Y, Zhang GY, Wang HZ, He MX, Xie LP#, Zhang RQ#. Novel Basic Protein, PfN23, Functions as a Key Macromolecule during Nacre Formation. Journal of Biological Chemistry, 2012: 287(19), 15776–15785.

  • Fang D, Pan C, Lin HJ, Lin Y, Xu GR, Zhang GY, Wang HZ, Xie LP#, Zhang RQ#. Ubiquitylation Functions in the Calcium Carbonate Biomineralization in the Extracellular Matrix. PLOS ONE, 2012: 7(4): e35715.

  • Fang D, Xu GR, Hu YL, Pan C, Xie LP#, Zhang, RQ#. Identification of genes directly involved in shell formation and their functions in pearl oyster, PinctadafucataPLOS ONE, 2011: 6(7): e21860.

Books:

  • Fang D, Wang H, Zhang Z. Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. In: Orsi G, Almouzni G. (eds) Histone Variants. Methods in Molecular Biology, 2018, vol 1832. Humana Press, New York, NY

  • Zhang Y, Sun Z, Jia J, Du T, Zhang N, Tang Y, Fang Y, Fang D#. Overview of Histone Modification. Adv Exp Med Biol, 2021, 1283, 1-16.

*co-first author, #correspondence author



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